Anti-GQ1b Ganglioside Antibody in Peripheral Nervous System Disorders
نویسندگان
چکیده
منابع مشابه
Anti-GQ1b ganglioside antibody in peripheral nervous system disorders: pathophysiologic role and clinical relevance.
The recent literature about autoimmune peripheral neuropathies has been dominated by the discovery of antibodies to a variety of glycosphingolipids. Gangliosides are important carbohydrate determinants for autoimmune activity, and several studies have suggested that serum antibodies against gangliosides are responsible for some forms of acute and chronic neuropathy syndromes. However, this view...
متن کاملAnti-GQ1b ganglioside antibody and ophthalmoplegia of undetermined cause.
BACKGROUND/AIM Serum antibody against ganglioside GQ1b is reported to be closely associated with immune mediated ophthalmoplegia in the Fisher and Guillain-Barré syndromes. Its presence against glycolipids, in particular ganglioside GQ1b, was investigated in patients with ophthalmoplegia of unknown origin. METHODS 16 patients with ophthalmoplegia, the cause of which could not be confirmed fro...
متن کاملAnti-GQ1b antibody syndrome: anti-ganglioside complex reactivity determines clinical spectrum.
BACKGROUND AND PURPOSE Anti-GQ1b antibodies have been found in patients with Miller Fisher syndrome as well as its related conditions. Our aim was to identify the mechanism by which autoantibodies produce various clinical presentations in 'anti-GQ1b antibody syndrome'. METHODS Immunoglobulin G antibodies to ganglioside complex (GSC) of GQ1b or GT1a with GM1, GD1a, GD1b or GT1b were tested in ...
متن کاملGQ1b ganglioside antibody-related disorders: a case with a complex phenotype.
We described an overlap syndrome associating Miller Fisher syndrome (MFS) and acute inflammatory demyelinating polyradiculoneuropathy (AIDP). Furthermore, the patient presented unusual neurological manifestations including headache, T10 sensory level, urinary urgency, and gadolinium enhancement of the spinal roots. One year follow-up was characterized by clinical recovery and persistent high ra...
متن کاملImmunotherapy for anti-GQ1b IgG antibody-mediated disorders: role of electrophysiology in human trials.
Sir, We read with interest the use of eculizumab as a protection against complement-mediated damage in a murine model of the Miller Fisher syndrome (MFS). This monoclonal antibody not only resulted in protection against functional and morphological terminal motor neuropathy, but effectively prohibited respiratory muscle paralysis (Halstead et al., 2008). These important findings have provided t...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2004
ISSN: 0003-9942
DOI: 10.1001/archneur.61.7.1013